PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION

• Main Authors: PARKANYI, ZSOLT, DOMBRADY, ZSOLT, FRIESZ, ANTAL
• Format: Patent
• Language: English; French
• Published: 04.10.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3-CH3 (III), where L is a leaving group, and isolating the obtained product and, i...