PRODUCTION OF ISOPRENOID IN RECOMBINANT YEAST

• Main Authors: SAUCY, GABRIEL G, MILLIS, JAMES R, MCMULLIN, THOMAS W, MAURINA-BRUNKER, JULIE
• Format: Patent
• Language: English; French
• Published: 15.05.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW PLANTS OR PROCESSES FOR OBTAINING THEM; ORGANIC CHEMISTRY; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TRAPPING; VINEGAR; WINE

The invention provides a method of producing .alpha.-tocopherol and .alpha.-tocopheryl esters and a method of producing vitamin A or .beta.-carotene. The methods comprise using a biological system to produce farnesol or geranylgeraniol. Then, the farnesol or geranylgeraniol is chemically converted into .alpha.-tocopherol, an .alpha.-tocopheryl ester, vitamin A or .beta. carotene