COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

• Main Authors: BINCH, HAYLEY MARIE, FANNING, LEV TYLER DEWEY, HURLEY, DENNIS JAMES, JOSHI, PRAMOD, CHARRIER, JEAN-DAMIEN, DURRANT, STEVEN JOHN, KAY, DAVID, PINDER, JOANNE, GROTE, MATTHEW PAUL, VIRANI, ANISA NIZARALI, YOUNG, STEPHEN CLINTON, REAPER, PHILIP MICHAEL, CLEVELAND, THOMAS, O'DONNELL, MICHAEL, STORCK, PIERRE-HENRI, KNEGTEL, RONALD MARCELLUS ALPHONSUS
• Format: Patent
• Language: English; French
• Published: 17.11.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I wherein the variables are as defined herein.