FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND PCSK9

• Main Authors: LOW, CHEE MENG, MITCHELL, TRACY S, LO, CHING-HSIUNG FREDERICK, DAVIS, JONATHAN H, CAMPHAUSEN, RAY, CLOAD, SHARON T, RAKESTRAW, GINGER C, SAEED-KOTHE, AMNA, MIAO, BOWMAN, SITKOFF, DOREE F, LIPOVSEK, DASA, RUSSO, KATIE A, DENHEZ, FABIENNE M, PARKER, REX A
• Format: Patent
• Language: English; French
• Published: 24.03.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein. La présente invention concerne des protéines à domaine de squelette basé sur la fibronectine qui se lient à PCSK9. L'invention concerne également l'utilisation des protéines innovantes dans des applications thérapeutiques pour traiter l'athérosclérose, l'hypercholestérolémie et d'autres maladies associées au cholestérol. L'invention concerne en outre des cellules comprenant de telles protéines, des polynucléotides codant pour de telles protéines ou des fragments de celles-ci, et des vecteurs comprenant les polynucléotides codant pour les protéines innovantes.