METHOD FOR THE PRODUCTION OF A CELL AND/OR TISSUE AND/OR DISEASE PHASE SPECIFIC MEDICAMENT
The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell type, tissue and/or stage specific proteins and nucleic acids are identified with regard to their modified expression pattern...
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Format | Patent |
Language | English French |
Published |
19.05.2015
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Abstract | The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell type, tissue and/or stage specific proteins and nucleic acids are identified with regard to their modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and autoimmune diseases is provided.
La présente invention concerne un procédé servant à produire un médicament spécifique de cellules ou de tissus ou de phases de maladies et convenant au traitement de maladies inflammatoires chroniques. À cet effet, des protéines et des acides nucléiques précis de la maladie, du type de cellule, du tissu ou du stade de la maladie sont recensés pour ce qui est de leur profil d'expression modifié, et les acides nucléiques correspondants sont analysés en tant que cibles d'attaque possibles pour des ADNzymes ou des ARNsi. Sensuit la conception des ADNzymes et des ARNsi spécifiques actifs qui se lient à la séquence cible et qui la clivent, de façon à ce quun médicament contre des maladies inflammatoires chroniques et contre des maladies auto-immunes soit obtenu. |
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AbstractList | The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell type, tissue and/or stage specific proteins and nucleic acids are identified with regard to their modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and autoimmune diseases is provided.
La présente invention concerne un procédé servant à produire un médicament spécifique de cellules ou de tissus ou de phases de maladies et convenant au traitement de maladies inflammatoires chroniques. À cet effet, des protéines et des acides nucléiques précis de la maladie, du type de cellule, du tissu ou du stade de la maladie sont recensés pour ce qui est de leur profil d'expression modifié, et les acides nucléiques correspondants sont analysés en tant que cibles d'attaque possibles pour des ADNzymes ou des ARNsi. Sensuit la conception des ADNzymes et des ARNsi spécifiques actifs qui se lient à la séquence cible et qui la clivent, de façon à ce quun médicament contre des maladies inflammatoires chroniques et contre des maladies auto-immunes soit obtenu. |
Author | SEL, SERDAR RENZ, HARALD |
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DocumentTitleAlternate | PROCEDE POUR PRODUIRE UN MEDICAMENT SPECIFIQUE DE CELLULES ET/OU DE TISSUS ET/OU DE PHASES DE MALADIES |
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RelatedCompanies | STERNA BIOLOGICALS GMBH & CO. KG |
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Snippet | The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases.... |
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Title | METHOD FOR THE PRODUCTION OF A CELL AND/OR TISSUE AND/OR DISEASE PHASE SPECIFIC MEDICAMENT |
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