METHOD FOR THE PRODUCTION OF A CELL AND/OR TISSUE AND/OR DISEASE PHASE SPECIFIC MEDICAMENT

The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell type, tissue and/or stage specific proteins and nucleic acids are identified with regard to their modified expression pattern...

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Main Authors RENZ, HARALD, SEL, SERDAR
Format Patent
LanguageEnglish
French
Published 19.05.2015
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Abstract The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell type, tissue and/or stage specific proteins and nucleic acids are identified with regard to their modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and autoimmune diseases is provided. La présente invention concerne un procédé servant à produire un médicament spécifique de cellules ou de tissus ou de phases de maladies et convenant au traitement de maladies inflammatoires chroniques. À cet effet, des protéines et des acides nucléiques précis de la maladie, du type de cellule, du tissu ou du stade de la maladie sont recensés pour ce qui est de leur profil d'expression modifié, et les acides nucléiques correspondants sont analysés en tant que cibles d'attaque possibles pour des ADNzymes ou des ARNsi. Sensuit la conception des ADNzymes et des ARNsi spécifiques actifs qui se lient à la séquence cible et qui la clivent, de façon à ce quun médicament contre des maladies inflammatoires chroniques et contre des maladies auto-immunes soit obtenu.
AbstractList The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell type, tissue and/or stage specific proteins and nucleic acids are identified with regard to their modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and autoimmune diseases is provided. La présente invention concerne un procédé servant à produire un médicament spécifique de cellules ou de tissus ou de phases de maladies et convenant au traitement de maladies inflammatoires chroniques. À cet effet, des protéines et des acides nucléiques précis de la maladie, du type de cellule, du tissu ou du stade de la maladie sont recensés pour ce qui est de leur profil d'expression modifié, et les acides nucléiques correspondants sont analysés en tant que cibles d'attaque possibles pour des ADNzymes ou des ARNsi. Sensuit la conception des ADNzymes et des ARNsi spécifiques actifs qui se lient à la séquence cible et qui la clivent, de façon à ce quun médicament contre des maladies inflammatoires chroniques et contre des maladies auto-immunes soit obtenu.
Author SEL, SERDAR
RENZ, HARALD
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DocumentTitleAlternate PROCEDE POUR PRODUIRE UN MEDICAMENT SPECIFIQUE DE CELLULES ET/OU DE TISSUS ET/OU DE PHASES DE MALADIES
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Snippet The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases....
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SubjectTerms BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Title METHOD FOR THE PRODUCTION OF A CELL AND/OR TISSUE AND/OR DISEASE PHASE SPECIFIC MEDICAMENT
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