DRAIN DOWN AND RE-FEED OF MICROCARRIER BIOREACTOR

• Main Authors: GUERTIN, PATRICK M, CROWELL, JOSEPH D
• Format: Patent
• Language: English; French
• Published: 16.10.2018
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

A method of increasing product yield per culture in a population of product-secreting cells bound to a scaffold at least partially immersed in a culture medium in a bioreactor is disclosed. The method comprises: removing a volume of the culture medium with a first-secreted product concentration from...