METHOD FOR PRODUCING HIGH AMOUNT OF GLYCOLIC ACID BY FERMENTATION

• Main Authors: SOUCAILLE, PHILIPPE, DISCHERT, WANDA
• Format: Patent
• Language: English; French
• Published: 06.07.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to an improved method for the bioconversion of a fermentable carbon source to glycolic acid by a recombinant microorganism bearing new genetic modifications such as .DELTA.IdhA, .DELTA.mgsA, .DELTA.arcA, and .DELTA.IIdP, .DELTA.gIcA, .DELTA.yjcG and combination of them allowing a production with higher yield, titer and productivity. La présente invention concerne un procédé amélioré permettant la bioconversion d'une source carbonée fermentable en acide glycolique par un microorganisme recombinant portant des modifications génétiques telles que ?ldhA, ?mgsA, ?arcA, et ?lIdP, ?gIcA, ?yjcG et une combinaison de ces modifications qui permettent une production avec un rendement, une pureté et une productivité plus élevés.