CYSTEINE PROTEASE INHIBITORS
Compounds of the formula I wherein R1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy; or R2a and R2b together with the carbon atom to which they are attac...
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Main Authors | , , , , , , , , , , , , |
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Format | Patent |
Language | English French |
Published |
24.06.2010
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Subjects | |
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Abstract | Compounds of the formula I wherein R1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy; or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl; R is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl, R4 is Het, Carbocyclyl, optionally substituted as defined in the specification and pharmaceutically acceptable salts, hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain |
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AbstractList | Compounds of the formula I wherein R1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy; or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl; R is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl, R4 is Het, Carbocyclyl, optionally substituted as defined in the specification and pharmaceutically acceptable salts, hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain |
Author | WAHLING, HORST ODEN, LOURDES GRABOWSKA, URSZULA KAHNBERG, PIA NILSSON, MAGNUS BELFRAGE, ANNA KARIN LIND, PETER HEWITT, ELLEN JONSSON, DANIEL PELCMAN, MIKAEL CLASSON, BJORN IVANOV, VLADIMIR AYESA, SUSANA |
Author_xml | – fullname: AYESA, SUSANA – fullname: PELCMAN, MIKAEL – fullname: IVANOV, VLADIMIR – fullname: KAHNBERG, PIA – fullname: GRABOWSKA, URSZULA – fullname: LIND, PETER – fullname: NILSSON, MAGNUS – fullname: WAHLING, HORST – fullname: CLASSON, BJORN – fullname: HEWITT, ELLEN – fullname: JONSSON, DANIEL – fullname: ODEN, LOURDES – fullname: BELFRAGE, ANNA KARIN |
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DocumentTitleAlternate | INHIBITEURS DE CYSTEINE PROTEASE |
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Snippet | Compounds of the formula I wherein R1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring... |
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Title | CYSTEINE PROTEASE INHIBITORS |
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