HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer.

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Main Authors BENCSIK, JOSEF R, CHABOT, CHRISTINE, XU, RUI, KALLAN, NICHOLAS C, ZHANG, BIRONG, BLAKE, JAMES F, DO, STEVEN, MITCHELL, IAN S, SPENCER, KEITH LEE, LIANG, JUN, SAFINA, BRIAN, XIAO, DENGMING
Format Patent
LanguageEnglish
French
Published 16.07.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer.
AbstractList The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer.
Author KALLAN, NICHOLAS C
SAFINA, BRIAN
DO, STEVEN
ZHANG, BIRONG
LIANG, JUN
BENCSIK, JOSEF R
XIAO, DENGMING
CHABOT, CHRISTINE
XU, RUI
BLAKE, JAMES F
SPENCER, KEITH LEE
MITCHELL, IAN S
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– fullname: BLAKE, JAMES F
– fullname: DO, STEVEN
– fullname: MITCHELL, IAN S
– fullname: SPENCER, KEITH LEE
– fullname: LIANG, JUN
– fullname: SAFINA, BRIAN
– fullname: XIAO, DENGMING
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DocumentTitleAlternate PYRIMIDYLCYCLOPENTANES HYDROXYLES UTILISES COMME INHIBITEURS DE PROTEINE KINASE AKT
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Snippet The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
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