N'-(PHENYL)-N-(MORPHOLIN-4-YL-PYRIDIN-2-YL) -PYRIMIDINE-2, 4-DIAMINE DERIVATIVES AS EPHB4 KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE CONDITIONS

The invention concerns pyrimidine com pounds of Formula (I), or a pharmac eutically acceptable salt thereof where A1, A2, A3, R1, n, R2, R3, and R4 ar e as defined in the description. The present invention also relates to pr oc esses for the preparation of such compounds, pharmaceutical compositions...

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Main Authors DUCRAY, RICHARD, BARLAAM, BERNARD CHRISTOPHE
Format Patent
LanguageEnglish
French
Published 06.11.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention concerns pyrimidine com pounds of Formula (I), or a pharmac eutically acceptable salt thereof where A1, A2, A3, R1, n, R2, R3, and R4 ar e as defined in the description. The present invention also relates to pr oc esses for the preparation of such compounds, pharmaceutical compositions con taining them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other p roliferative conditions which are sensitive to th e inhibition of EphB4 kina ses.
AbstractList The invention concerns pyrimidine com pounds of Formula (I), or a pharmac eutically acceptable salt thereof where A1, A2, A3, R1, n, R2, R3, and R4 ar e as defined in the description. The present invention also relates to pr oc esses for the preparation of such compounds, pharmaceutical compositions con taining them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other p roliferative conditions which are sensitive to th e inhibition of EphB4 kina ses.
Author BARLAAM, BERNARD CHRISTOPHE
DUCRAY, RICHARD
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DocumentTitleAlternate NOUVEAUX DERIVES DE N' - (PHENYL) -N- (MORPHOLIN-4-YL-PYRIDIN-2-YL) -PYRIMIDINE-2, 4-DIAMINEPYRIMIDINE EN TANT QU'INHIBITEURS DE EPHB4 KINASE POUR LE TRAITEMENT D'ETATS PROLIFERATIFS
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Snippet The invention concerns pyrimidine com pounds of Formula (I), or a pharmac eutically acceptable salt thereof where A1, A2, A3, R1, n, R2, R3, and R4 ar e as...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title N'-(PHENYL)-N-(MORPHOLIN-4-YL-PYRIDIN-2-YL) -PYRIMIDINE-2, 4-DIAMINE DERIVATIVES AS EPHB4 KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE CONDITIONS
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