CAPECITABINE PEDIATRIC TABLETS

There is provided a film coated pharmaceutical composition comprising 5'-deoxy-5-fluoro-N-[(pentyloxy)-carbonyl]-cytidine (capecitabine) and at least one disintegrant selected from the group comprising of crospovidone (particle size <15-400 µ), croscarmellose sodium, sodium starch glycolate,...

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Bibliographic Details
Main Authors SHAH, NAVNIT HARGOVINDAS, INFELD, MARTIN HOWARD, BACHYNSKY, MARIA OKSANA, RASHED, MOHAMMAD
Format Patent
LanguageEnglish
French
Published 30.06.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:There is provided a film coated pharmaceutical composition comprising 5'-deoxy-5-fluoro-N-[(pentyloxy)-carbonyl]-cytidine (capecitabine) and at least one disintegrant selected from the group comprising of crospovidone (particle size <15-400 µ), croscarmellose sodium, sodium starch glycolate, low- substituted hydroxypropylcellulose, Pharmaburst C or any combination of these, together with other pharmaceutically acceptable excipients to form a rapidly disintegrating tablet. This tablet disintegrates in water at 37°C in a USP Disintegration Apparatus in less than 2 minutes, preferably 1 minute and have a hardness of 8-13 strong Cobb-Units.
Bibliography:Application Number: CA20072664922