HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 ANTIBODIES

• Main Authors: HOLMES, ERIC H, BRAMS, PETER, WITTE, ALISON, VISTICA, CYNTHIA A, CARDARELLI, JOSEPHINE M
• Format: Patent
• Language: English; French
• Published: 23.09.2014
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies. L'invention concerne des anticorps monoclonaux isolés, en particulier des anticorps monoclonaux humains se liant spécifiquement au fucosyl-GM1 avec une haute affinité. L'invention concerne en outre des molécules d'acide nucléique codant les anticorps spécifiés dans la description, des vecteurs d'expression, des cellules hôtes, ainsi que des procédés d'expression des anticorps spécifiés. De plus, l'invention concerne des immuno-conjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps spécifiés. L'invention concerne également des procédés de détection de fucosyl-GM1, ainsi que des procédés de traitement de diverses maladies, y compris le cancer, au moyen des anticorps anti-fucosyl-GM1.