HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES

The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing suc h compounds. In another embodiment, the invention discloses pharmaceutical compositi...

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Main Authors HIPSKIND, PHILIP ARTHUR, JESUDASON, CYNTHIA DARSHINI, PICKARD, RICHARD TODD, BEAVERS, LISA SELSAM, TAKAKUWA, TAKAKO, GADSKI, ROBERT ALAN, VAUGHT, GRANT MATHEWS, HORNBACK, WILLIAM JOSEPH, FINLEY, DON RICHARD
Format Patent
LanguageEnglish
French
Published 11.01.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing suc h compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histami ne H3 receptor-related diseases. (Formula I)
Bibliography:Application Number: CA20062613192