PYRROLIDINE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS
The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharm...
Saved in:
| Main Authors | , , , , , , , |
|---|---|
| Format | Patent |
| Language | English French |
| Published |
28.09.2006
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. |
|---|---|
| AbstractList | The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. |
| Author | BEAVERS, LISA SELSAM STEVENS, FREDDIE CRAIG FINLEY, DON RICHARD PICKARD, RICHARD TODD GADSKI, ROBERT ALAN TAKAKUWA, TAKAKO JESUDASON, CYNTHIA DARSHINI HIPSKIND, PHILIP ARTHUR |
| Author_xml | – fullname: HIPSKIND, PHILIP ARTHUR – fullname: JESUDASON, CYNTHIA DARSHINI – fullname: PICKARD, RICHARD TODD – fullname: BEAVERS, LISA SELSAM – fullname: TAKAKUWA, TAKAKO – fullname: GADSKI, ROBERT ALAN – fullname: FINLEY, DON RICHARD – fullname: STEVENS, FREDDIE CRAIG |
| BookMark | eNrjYmDJy89L5WSwCYgMCvL38XTx9HNVcHEN8gxzDPEMcw1WcAxW8PAMDnH0BUl4GCsEuTq7BoT4Byk4-oU4uvv7AeWCeRhY0xJzilN5oTQ3g4Kba4izh25qQX58anFBYnJqXmpJvLOjkZmBgbmpuaOhMRFKAN_MKxQ |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | DERIVES DE PYRROLIDINE COMME ANTAGONISTES DE RECEPTEURS H3 DE L~HISTAMINE |
| ExternalDocumentID | CA2600757A1 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_CA2600757A13 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 14:17:26 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English French |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_CA2600757A13 |
| Notes | Application Number: CA20062600757 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060928&DB=EPODOC&CC=CA&NR=2600757A1 |
| ParticipantIDs | epo_espacenet_CA2600757A1 |
| PublicationCentury | 2000 |
| PublicationDate | 20060928 |
| PublicationDateYYYYMMDD | 2006-09-28 |
| PublicationDate_xml | – month: 09 year: 2006 text: 20060928 day: 28 |
| PublicationDecade | 2000 |
| PublicationYear | 2006 |
| RelatedCompanies | ELI LILLY AND COMPANY |
| RelatedCompanies_xml | – name: ELI LILLY AND COMPANY |
| Score | 2.6546192 |
| Snippet | The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | PYRROLIDINE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060928&DB=EPODOC&locale=&CC=CA&NR=2600757A1 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bS8MwFD6MKeqbTsV5Iw_St-Js1xtYJEszW3FtaWOZT8NmHeylG67i3_e0btMXfQs5cMiFL_lOkvMF4GZq5oUha-Xj2Zul9qd6T7UNjFoLnO8C-a51J-sb3VFo-i_9p7ExbsF8kwvT6IR-NuKIiCiJeK-a9Xr5c4jlNW8rV7f5HKsWD0Pheso2Ou45mq14A5fHkRcxhTGXUSVM3EaH3bAoBko7yKKtGgw8G9RJKcvfO8rwEHZjdFZWR9Aqyg7ss83Hax3YG63vu7G4ht7qGO7j1ySJngMvCDnxMPzKqAgynhKaEj9IBR3VBl8nCWc8FlFCaCjoYxSiLT0BMuSC-So2Y7Lt8oTRbYP1U2iXi7I4A6KbjkT6M7N0icBzZk5uSIkcQto5MgVb60L3Tzfn_9gu4OD7ZMFRNfsS2tX7R3GFe22VXzej9AUCUHy2 |
| link.rule.ids | 230,309,783,888,25576,76876 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bT8IwFD4haMQ3RY147YPZ2yIyxrbExZSuuCm7ZKsEn4grI-FlEJnx73s2AX3Rt6YnOeklX_udtucrwM20l2a6LJWPZ2-G2p1qbdXUMWrNcL4z5LvGnSxvdP2g5750n8b6uAbzTS5MpRP6WYkjIqIk4r2o1uvlzyGWU72tXN2mc6xaPAyE7Sjb6LhtdUzF6ds8Cp2QKYzZjCpBbFc67LpBMVDaQYZtlGDgo36ZlLL8vaMMDmA3Qmd5cQi1LG9Cg20-XmvCnr--78biGnqrI7iPXuM4HHqOF3DiYPg1osIb8YTQhLheIqhfGlyNxJzxSIQxoYGgj2GAtuQYyIAL5qrYjMm2yxNGtw3WTqCeL_LsFIjWsyTSn5mhSQSeNbNSXUrkENJMkSmYnRa0_nRz9o_tGhqu8IeToRc8n8P-9ymDpXbMC6gX7x_ZJe67RXpVjdgXBpJ_qQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=PYRROLIDINE+DERIVATIVES+AS+HISTAMINE+H3+RECEPTOR+ANTAGONISTS&rft.inventor=HIPSKIND%2C+PHILIP+ARTHUR&rft.inventor=JESUDASON%2C+CYNTHIA+DARSHINI&rft.inventor=PICKARD%2C+RICHARD+TODD&rft.inventor=BEAVERS%2C+LISA+SELSAM&rft.inventor=TAKAKUWA%2C+TAKAKO&rft.inventor=GADSKI%2C+ROBERT+ALAN&rft.inventor=FINLEY%2C+DON+RICHARD&rft.inventor=STEVENS%2C+FREDDIE+CRAIG&rft.date=2006-09-28&rft.externalDBID=A1&rft.externalDocID=CA2600757A1 |