INHIBITORS OF AKT ACTIVITY

• Main Authors: HARTNETT, JOHN C, EASTMAN, BRIAN W, WU, ZHICAI, NEILSON, LOU ANNE, COSFORD, NICHOLAS D. P, BILODEAU, MARK T, HU, ESSA H, TEHRANI, LIDA R, MANLEY, PETER J, CHEN, CHIXU
• Format: Patent
• Language: English; French
• Published: 27.10.2005
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer c...