PROCESS FOR THE PREPARATION OF CHIRAL PROPIONIC ACID DERIVATIVES

The present invention is concerned with a novel process for the preparation of compounds of formula (I) comprising catalytic asymmetric hydrogenation of a compound of formula (II) in the presence of a catalyst comprising ruthenium and a chiral diphosphine ligand or comprising rhodium and a chiral di...

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Bibliographic Details
Main Authors SCALONE, MICHELANGELO, PUENTENER, KURT
Format Patent
LanguageEnglish
French
Published 05.01.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is concerned with a novel process for the preparation of compounds of formula (I) comprising catalytic asymmetric hydrogenation of a compound of formula (II) in the presence of a catalyst comprising ruthenium and a chiral diphosphine ligand or comprising rhodium and a chiral diphosphine ligand, wherein R1, R2, R3 and R4 are as defined in the specification and claims. The compounds of formula (I) and the corresponding salts and/or esters are pharmaceutically active substances. La présente invention concerne un nouveau procédé de préparation de composés de la formule (1) qui consiste à effectuer une hydrogénation asymétrique catalytique d'un composé de la formule (2) en présence d'un catalyseur comprenant du ruthénium et un ligand diphosphine chiral ou comprenant du rhodium et un ligand diphosphine chiral, dans laquelle R?1¿, R?2¿, R?3¿ et R?4¿ sont tels que définis dans la spécification et les revendications. Les composés de la formule 1 et les sels et/ou esters correspondants sont des substances pharmaceutiquement actives.
Bibliography:Application Number: CA20042539176