NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 191P4D12(B) USEFUL IN TREATMENT AND DETECTION OF CANCER

• Main Authors: FARIS, MARY, RAITANO, ARTHUR B, JAKOBOVITS, AYA, CHALLITA-EID, PIA M, GE, WANGMAO
• Format: Patent
• Language: English; French
• Published: 18.02.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization. L'invention concerne un nouveau gène 191P4D12(b) et sa protéine codée, ainsi que des variants de celle-ci. 191P4D12(b) présente une expression spécifique au tissu dans un tissu adulte normal et s'exprime de manière aberrante dans les cancers énumérés dans le tableau I. En conséquence, 191P4D12(b) fournit une cible diagnostique, pronostique, prophylactique et/ou thérapeutique relative au cancer. Le gène 191P4D12(b) ou un fragment de celui-ci, ou sa protéine codée, ou des variants de celle-ci, ou un fragment de celle-ci peuvent servir à obtenir une réponse immunitaire humorale ou cellulaire. On peut également utiliser des anticorps ou des lymphocytes T réactifs au 191P4D12(b) en immunisation active ou passive.