SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION

Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/ or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer~s Disease and Down...

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Main Authors MOORE, WILLIAM JAY, STOCK, JOSEPH RAYMOND, KREFT, ANTHONY FRANK, MANN, CHARLES WILLIAM, WOLLER, KEVIN ROGER, CASEBIER, DAVID SCOTT, COLE, DEREK CECIL, KUBRAK, DENNIS MICHAEL, KUTTERER, KRISTINA MARTHA
Format Patent
LanguageEnglish
French
Published 18.12.2003
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/ or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer~s Disease and Down~s syndrome are described.
Bibliography:Application Number: CA20032486581