THERMOTHERAPY VIA TARGETED DELIVERY OF NANOSCALE MAGNETIC PARTICLES

• Main Authors: HANDY, ERIK S, ARDMAN, BLAIR, ELLIS-BUSBY, DIANE, IVKOV, ROBERT, FOREMAN, ALLAN, BRAUNHUT, SUSAN J, JAHNGEN, EDWIN G. E, GWOST, DOUGLAS U
• Format: Patent
• Language: English; French
• Published: 20.03.2003
• Edition: 7
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ELECTROTHERAPY; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROSTHESES; RADIATION THERAPY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TREATMENT OR PROTECTION OF EYES OR EARS; ULTRASOUND THERAPY

Disclosed are therapeutic methods for the treatment of diseased, disease- causing, or undesirable tissue or material that involve the administration o f a thermotherpeutic magnetic composition, which contains single-domain magnet ic particles attached to a target-specific ligand, to a patient and the application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods for administration of the thermotherapeutic magnetic composition. These therapeutic methods may be used where the predetermined target is associated with a disease, such as cancer, diseases of the immune system, pathogen-born e diseases, obesity, hormone-related diseases, Alzheimer's disease, disease precursor, and undesirable materials, such as undesirable adipose tissue, reactions to organ transplants, HIV infected cells, polypeptides receptors, blood clots, and low density lipoproteins.