2-HETEROARYL-IMIDAZOTRIAZINONES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES

• Main Authors: NIEWOEHNER, ULRICH, SCHAUSS, DAGMAR, HENDRIX, MARTIN, GEISS, VOLKER, FITZGERALD, MARY F, BISCHOFF, HILMAR, STURTON, GRAHAM, BURKHARDT, NILS, SCHLEMMER, KARL-HEINZ, CUTHBERT, NIGEL, ALONSO-ALIJA, CRISTINA, GIELEN, HEIKE
• Format: Patent
• Language: English; French
• Published: 12.12.2002
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to 2-Heteroaryl-imidazotriazinones, processes for thei r preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R1 denote s 5- to 10- membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C1-C4)- alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3-to 10- membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, where by carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C1-C6)-aldyl, (C1- C6)-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C2-C10)- alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C1-C6)-alkoxy, hydroxy, halogen, 3-to 10-membered carbocyclyl and oxo.