DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES

• Main Authors: BENEDICT, SUZANNE PRITCHETT, PENG, ZHENGWEI, TEMPCZYK-RUSSELL, ANNE MARIA, ALEGRIA, LARRY ANDREW, CHU, SHAO SONG, BENDER, STEVEN LEE, YANG, YI MICHELLE, BHUMRALKAR, DILIP, SARSHAR, SEPEHR, BORCHARDT, ALLEN J, KANIA, ROBERT STEVE, NAMBU, MITCHELL DAVID
• Format: Patent
• Language: English; French
• Published: 14.12.2000
• Edition: 7
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Diaminothiazole compounds of formula (I) that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosin e kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, a nd to methods of treating cancer as well as other disease states associated wit h unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.