PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES

The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula...

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Main Authors DEMATTEI, JOHN J, ALLEN, MICHAEL S, NICHOLS, PAUL J, PATEL, HEMANT H, CONDON, STEPHEN, KING, STEVEN A, PATEL, SUBHASH R, PREMCHANDRAN, RAMIYA H, TIEN, JIEN-HEH J, MANNA, SUKUMAR, STONER, ERIC J, CHANG, SOU-JEN, PLATA, DANIEL J, KOLACZKOWSKI, LAWRENCE, WITTENBERGER, STEVEN J
Format Patent
LanguageEnglish
French
Published 11.10.2011
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
Bibliography:Application Number: CA20002368768