SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL)BENZOHETEROARYLCOMPOUNDS

This invention is directed to an (aminoiminomethyl or aminomethyl)benzoheteroaryl compound of formula (I): wherein X is O, S or NR 1 which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to...

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Main Authors VOLZ, FRANCIS A, MCGARRY, DANIEL G, BURNS, CHRISTOPHER, GALLAGHER, TIMOTHY F, DANKULICH, WILLIAM P
Format Patent
LanguageEnglish
French
Published 06.07.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention is directed to an (aminoiminomethyl or aminomethyl)benzoheteroaryl compound of formula (I): wherein X is O, S or NR 1 which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of formula (I), methods f or their preparation, their use, such as in inhibiting the formation of thrombi n or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.</SD OAB>
Bibliography:Application Number: CA19992358047