INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS

• Main Authors: SCOTT, WILLIAM J, KHIRE, UDAY, WOOD, JILL E, LEE, WENDY, RENICK, JOEL, JOHNSON, JEFFREY, PAULSEN, HOLGER, LOWINGER, TIMOTHY BRUNO, DUMAS, JACQUES, SMITH, ROGER A, REDMAN, ANIKO, SIBLEY, ROBERT, HATOUM-MOKDAD, HOLIA, RIEDL, BERND
• Format: Patent
• Language: English; French
• Published: 01.02.2011
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.