NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Pyridazine derivatives represented by general formula (1) or salts thereof; and drugs containing the same as the active ingredient: wherein R1 is (substituted) aryl; R2 is phenyl substituted with lower alkoxy, lower alkylthio or the like at the position 4; R3 is H, lower alkoxy, lower haloalkyl, low...

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Main Authors MATSUDA, TAKAYUKI, OHGIYA, TADAAKI, YOSHIZAKI, HIDEO, OHKUCHI, MASAO, KITAMURA, TAKAHIRO, SHIGYO, HIROMICHI, KOTAKI, KYOKO, HABATA, YURIKO, KYOTANI, YOSHINORI, YAMAZAKI, YUKIYOSHI, KUMAI, NATSUYO, KOSHI, TOMOYUKI
Format Patent
LanguageEnglish
French
Published 30.06.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Pyridazine derivatives represented by general formula (1) or salts thereof; and drugs containing the same as the active ingredient: wherein R1 is (substituted) aryl; R2 is phenyl substituted with lower alkoxy, lower alkylthio or the like at the position 4; R3 is H, lower alkoxy, lower haloalkyl, lower cycloalkyl, (substituted) aryl, (substituted) aryloxy, (substituted) nitrogenous heterocyclic residue, (substituted) aminocarbonyl or lower alkyl--carbonyl; A is a single bond, lower alkylene or lower alkenylene; X is O or S; and the broken line between the carbon atoms at the positions 4 and 5 represents a single or double bond. These compounds exhibit excellent inhibitory activity against the production of interleukin 1.beta., thus being useful as preventive and therapeutic drugs for immunologic diseases, inflammatory diseases, ischemic diseases and so on.
Bibliography:Application Number: CA19982307111