FIXED-DOSE ASSOCIATION OF AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR AND OF A CALCIUM CHANNEL ANTAGONIST, METHOD FOR PREPARATION AND USETHEREOF IN THE TREATMENT OF CARDIOVASCULARILLNESSES
FIXED-DOSE ASSOCIATION OF AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR AND OF A CALCIUM CHANNEL ANTAGONIST, METHOD FOR PREPARATION AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR ILLNESSES Comprises a dose of (a) enalapril or a pharmaceutically acceptable salt thereof and another dose of (b) nitren...
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Main Authors | , , |
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Format | Patent |
Language | English French |
Published |
10.08.2004
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | FIXED-DOSE ASSOCIATION OF AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR AND OF A CALCIUM CHANNEL ANTAGONIST, METHOD FOR PREPARATION AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR ILLNESSES Comprises a dose of (a) enalapril or a pharmaceutically acceptable salt thereof and another dose of (b) nitrendipine or a pharmaceutically acceptable salt thereof and in that it is administered in single-dose gallenic form. The method comprises: (a) dissolving enalapril maleate in water with an inorganic salt; (b) mixing the micronized nitrendipine with a fraction of she disintegrating excipients, the wetting agent, the fragmentary diluting agent, the agglutinating agent, and the plastic diluting agent, previously sieved; (c) granulating- the products homogenized in section (b) with the solution obtained in section (a); (d) drying the granulated mass; (e) incorporating the lubricating agent, and the remaining fraction of the disintegrating excipients and homogenizing the calibrated granulate; (f) compressing the granulate. Use of said association for the manufacture of a medicament for the treatment of illnesses of the cardiovascular system. |
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Bibliography: | Application Number: CA19982234899 |