NOVEL ISOQUINOLINE DERIVATIVES

• Main Authors: OKUE, MASAYUKI, ISHIGURO, SUSUMU, YAGI, YUZO, SEYA, MOTOHIDE, SHIMADA, SHINICHI, OGANE, NOBUO, SAITOU, YASUNARI
• Format: Patent
• Language: English; French
• Published: 12.02.1998
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention aims to provide new compounds having inhibitory activity of apoptotic neuronal cell death, and new isoquinoline derivatives and pharmaceutically acceptable acid addition salts represented by the following general formula (I) are obtained. (see formula I) wherein Ar shows an aromatic ring which may be substituted, and n shows 0, 1 or 2. The compounds of the present invention have inhibitory activity of neuronal cell death, and they are useful for agents of prevention and treatment of neuronal neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's chorea and amyotrophic lateral sclerosi s, cerebral ischemic injury such as stroke, and peripheral neuropathy in diabet es mellitus. Novel isoquinoline derivatives represented by general formula (I) or pharmaceutically acceptable acid-addition salts thereof, prepared by aiming at providing novel compounds which have an inhibitory activity on nerve cell death of the apoptosis type, wherein Ar represents an optionally substituted aromatic ring; and n is 0, 1 or 2. Because of the inhibitory effect on cell death, these compounds are useful as preventives and remedies for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's chorea and amyotrophic lateral sclerosis, ischemic cerebral diseases such as cerebral stroke, and peripheral nerve disorders observed in diabetes, etc.