PROCESS FOR THE PREPARATION OF A SUBSTITUTED 2.5-DIAMINO-3-HYDROXYHEXANE

A process is disclosed for the preparation of the substantially pure compound of formula (I) comprising catalytic hydrogenation of a compound of formula (II) wherein R6 and R7 are independently selected from (i) wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc...

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Bibliographic Details
Main Authors HAIGHT, ANTHONY R, ROBBINS, TIMOTHY A, GOODMONSON, OWEN J, SEIF, LOUIS S, PAREKH, SHYAMAL I
Format Patent
LanguageEnglish
French
Published 15.02.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:A process is disclosed for the preparation of the substantially pure compound of formula (I) comprising catalytic hydrogenation of a compound of formula (II) wherein R6 and R7 are independently selected from (i) wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b) wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; or an acid addition salt thereof.
Bibliography:Application Number: CA19952192836