PROCESS FOR BIOPHOSPHORYLATING ORGANIC COMPOUNDS
2093429 9206992 PCTABS00012 Described is a new microbial biophosphorylation process for regiospecifically phosphorylating the hydroxyl group, in a ''phosphate active'' hydroxyl containing organic compound, under biotransformation conditions utilizing the microorganism, Rhizopus o...
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Main Authors | , , , , , , , , , |
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Format | Patent |
Language | English French |
Published |
10.04.1992
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Edition | 5 |
Subjects | |
Online Access | Get full text |
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Abstract | 2093429 9206992 PCTABS00012 Described is a new microbial biophosphorylation process for regiospecifically phosphorylating the hydroxyl group, in a ''phosphate active'' hydroxyl containing organic compound, under biotransformation conditions utilizing the microorganism, Rhizopus oryzae) ATCC No. 11145. The phosphorylated compounds produced by the process include e.g., macrolide FK-506 type immunosuppressants which are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, kidney, lung and heart transplants. Other hydroxyl containing compounds, applicable in this process include rapamycin, echinocandins, HIV protease inhibitors, simvastatin and zearalenone. |
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AbstractList | 2093429 9206992 PCTABS00012 Described is a new microbial biophosphorylation process for regiospecifically phosphorylating the hydroxyl group, in a ''phosphate active'' hydroxyl containing organic compound, under biotransformation conditions utilizing the microorganism, Rhizopus oryzae) ATCC No. 11145. The phosphorylated compounds produced by the process include e.g., macrolide FK-506 type immunosuppressants which are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, kidney, lung and heart transplants. Other hydroxyl containing compounds, applicable in this process include rapamycin, echinocandins, HIV protease inhibitors, simvastatin and zearalenone. |
Author | CHEN, SHIEH-SHUNG T PETUCH, BRIAN R ARISON, BYRON H SO, LYDIA T HSU, ANNJIA T WHITE, RAYMOND F MATHRE, DAVID J DUMONT, FRANCIS REAMER, ROBERT A WU, JANE T |
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DocumentTitleAlternate | METHODE DE BIOPHOSPHORYLATION DES COMPOSES ORGANIQUES |
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SubjectTerms | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE |
Title | PROCESS FOR BIOPHOSPHORYLATING ORGANIC COMPOUNDS |
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