METHODS FOR REDUCING NON-TARGET RETENTION OF IMMUNOCONJUGATES AND METABOLITES THEREOF

Methods for reducing non-target retention of active moieties associated with immunoconjugates and their metabolites, and more specifically, for reducing renal retention of such active moieties, are disclosed. Methods of the present invention comprise administering an effective amount of a non-target...

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Main Authors AXWORTHY, DON, WILKENING, DAVID, GRAY, MARY A
Format Patent
LanguageEnglish
French
Published 27.02.2001
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Methods for reducing non-target retention of active moieties associated with immunoconjugates and their metabolites, and more specifically, for reducing renal retention of such active moieties, are disclosed. Methods of the present invention comprise administering an effective amount of a non-target reduction moiety, such as lysine, in addition to a therapeutically or diagnostically effective amount of an immunoconjugate. The non-target reduction moiety localizes in the kidneys and inhibits renal retention and reabsorption of active moieties associated with immunoconjugates and their metabolites.
AbstractList Methods for reducing non-target retention of active moieties associated with immunoconjugates and their metabolites, and more specifically, for reducing renal retention of such active moieties, are disclosed. Methods of the present invention comprise administering an effective amount of a non-target reduction moiety, such as lysine, in addition to a therapeutically or diagnostically effective amount of an immunoconjugate. The non-target reduction moiety localizes in the kidneys and inhibits renal retention and reabsorption of active moieties associated with immunoconjugates and their metabolites.
Author GRAY, MARY A
AXWORTHY, DON
WILKENING, DAVID
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DocumentTitleAlternate METHODES DE REDUCTION DE LA RETENTION NON RECHERCHEE D'IMMUNOCONJUGUES ET METABOLITES OBTENUS
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Snippet Methods for reducing non-target retention of active moieties associated with immunoconjugates and their metabolites, and more specifically, for reducing renal...
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title METHODS FOR REDUCING NON-TARGET RETENTION OF IMMUNOCONJUGATES AND METABOLITES THEREOF
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