CONJUGATION OF POLYMER TO COLONY STIMULATING FACTOR-1

• Main Authors: KATRE NANDINI, KOTHS, KIRSTON, E, MORELAND MARGARET, SHADLE, PAULA, J
• Format: Patent
• Language: English; French
• Published: 29.12.1998
• Edition: 6
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is biologically active and has increased circulating half-life in mammals, compared to that of the unconjugated protein. The conjugated CSF-1 may be used to stimulate the immune response or to provide more cells to be stimulated.