PYRIMIDINE DERIVATIVES

PYRIMIDINE DERIVATIVES The compounds of the general Formula I (I) and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy. In the general Formula I A stands for -CH2-CH2-, -CH2-CH2-CH2-, -CH2-CH2-CH2CH2- or -CH=CH-...

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Main Authors BOZSING, DANIEL, KOVANYI, GYORGYI NEE LAX, TUBOLY, SANDOR, BERENYI, EDIT NEE POLDERMANN, MAGYAR, KAROLY, MANDI, ATTILA
Format Patent
LanguageEnglish
French
Published 30.11.1993
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PYRIMIDINE DERIVATIVES The compounds of the general Formula I (I) and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy. In the general Formula I A stands for -CH2-CH2-, -CH2-CH2-CH2-, -CH2-CH2-CH2CH2- or -CH=CH-: R4 is hydrogen, C1-4 alkyl or optionally substituted phenyl; r is 0, 1, 2, 3 or 4; R1 stands for hydrogen or C1-5 alkanoyl; R2 represents hydrogen, C1-5 alkanoyl or a group of the general Formula (a) (a) wherein R stands for hydrogen, C1-4 alkyl, C2-4 alkenyl, phenyl or phenyl-C1-3 alkyl and R3 stands for hydrogen. The compounds of the general Formula I can be prepared by reacting a 2-mercapto-4,6-diamino-pyrimidine of the general Formula II (II) with a dihalo compound of the general Formula III (III) (wherein Y and Z are halogen).
Bibliography:Application Number: CA19870555670