ERGOLINE DERIVATIVES

The present invention provides novel bicyclic ergoline esters useful as serotonin antagonists. These esters are of the general formula (I): (I) wherein: R is a primary or secondary C1-C8 alkyl group, -CH2-C2-C4 alkenyl, C3-C8 cycloalkyl, or C3-C8 cycloalkyl substituted with one or more primary or se...

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Bibliographic Details
Main Authors FLUDZINSKI, PAWEL, GARBRECHT, WILLIAM L, MARZONI, GIFFORD P
Format Patent
LanguageEnglish
French
Published 02.06.1992
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides novel bicyclic ergoline esters useful as serotonin antagonists. These esters are of the general formula (I): (I) wherein: R is a primary or secondary C1-C8 alkyl group, -CH2-C2-C4 alkenyl, C3-C8 cycloalkyl, or C3-C8 cycloalkyl substituted with one or more primary or secondary C1-C5 alkyl groups, with the proviso that the total number of carbon atoms in R does not exceed 8; R1 is Cl-C4 alkyl; R2 is ; R3 is hydroxy, C1-C4 alkoxy, halo, C1-C4 alkyl or -?-R4; R4 is hydroxy, C1-C4 alkoxy or amino; m is 3, 4 or 5; n is 2, 3, 4 or 5; p is 0, 1, 2, or 3; or a pharmaceutically acceptable salt thereof.
Bibliography:Application Number: CA19880566319