PROCESS FOR THE PREPARATION OF HYDROCHLORIDES

• Main Authors: KUN, LAJOS, CSEKE, LASZLO, BALINT, JANOS, SZARVAS, MIKLOS, HORVATH, EVA (NEE FEHER), FABIAN, FERENC
• Format: Patent
• Language: English; French
• Published: 29.07.1986
• Edition: 4
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; DERIVATIVES THEREOF; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; STEROIDS; SUGARS

PROCESS FOR THE PREPARATION OF HYDROCHLIRIDES A b s t r a c t The invention relates to a process for the preparation of hydrochlorides, i.e. of acid addition salts formed with hydrochloric acid, particularly of compounds containing a protonatable nitrogen atom According to the process of the invention a compound useful to form a hydrochloride and being suitably in the form of a derivative containing protonatable nitrogen atom or in the form of a salt is reacted with a sulphonyl compound of the formula Q - SO2 - Cl, wherein Q stands for a hydroxyl, C1-4 alkyl or an aryl group, the latter being optionally substituted by a C1-4 alkyl group, in a solvent, in the presence of an alcohol, whereupon the hydrochloride obtained is recovered in a known manner.