anticorpos contra fator de crescimento de nervo (ngf) com estabilidade in vivo intensificada
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-...
Saved in:
| Main Authors | , , , , , , |
|---|---|
| Format | Patent |
| Language | Portuguese |
| Published |
29.11.2016
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided. |
|---|---|
| AbstractList | The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided. |
| Author | SANDEEP DUTTA WEI LIU ANDREA BEST DUNCAN CASSON JERRY A. HALL MARK MAGINN JOHN POWELL |
| Author_xml | – fullname: WEI LIU – fullname: JERRY A. HALL – fullname: SANDEEP DUTTA – fullname: DUNCAN CASSON – fullname: JOHN POWELL – fullname: ANDREA BEST – fullname: MARK MAGINN |
| BookMark | eNqNijsKwkAQQLfQwt8dBistBKPxACqKdiKWQhh3Z2UgmQm7Q85vBA9g9Xi8N3YDUaGRe6IYe02tZvAqlhAimiYIBD5R9tyQmH5VKHUKC3nHZb82QNnwxTUH7CMLdNxnFiPJHNljwKkbRqwzzX6cuPn59DheVtRqRblFT0JWHe63a7EuyrLc7Tfbv6YPYTU-FQ |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| ExternalDocumentID | BRPI1014445A2 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_BRPI1014445A23 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 14:54:25 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | Portuguese |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_BRPI1014445A23 |
| Notes | Application Number: BR2010PI14445 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161129&DB=EPODOC&CC=BR&NR=PI1014445A2 |
| ParticipantIDs | epo_espacenet_BRPI1014445A2 |
| PublicationCentury | 2000 |
| PublicationDate | 20161129 |
| PublicationDateYYYYMMDD | 2016-11-29 |
| PublicationDate_xml | – month: 11 year: 2016 text: 20161129 day: 29 |
| PublicationDecade | 2010 |
| PublicationYear | 2016 |
| RelatedCompanies | ABBOTT RESEARCH B.V |
| RelatedCompanies_xml | – name: ABBOTT RESEARCH B.V |
| Score | 3.0698197 |
| Snippet | The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| Title | anticorpos contra fator de crescimento de nervo (ngf) com estabilidade in vivo intensificada |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161129&DB=EPODOC&locale=&CC=BR&NR=PI1014445A2 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1dS8Mw8BhT1DedijqVIFL0oUg_tz4UsV9MYVspU_YgjLRNpYhtWav-fS-x0z3tLcmFkFy4z9xdAK41Rg11YGRyouixrMe6JsdUS-QhUyyLMdMcxNyhP56Yo2f9aW7MO_C-yoURdUK_RXFEpKgE6b0R_Lr6d2J5IrayvotzHCrvg5ntSa11jOoLyi_Jc2w_nHpTV3Jd24mkSWSHj_xTWl03HpBfb3E9mhfa918cnpZSrcuUYB-2Q1yuaA6gUzU92HVXX6_1YGfcvnhjsyW--hBeEQl4b8uqrImIMKck4yYzSRlB3Q9lGff0lbxbIAcoyU3xlt3i1A-CrF9U0k0pAvOCfOUIzn-j1zOeVEKP4CrwZ-5Ixm0u_pCycKK1I2nH0C3Kgp0AUS2qUoNmmZaiMYK9xECDM1WSock0y7ROob9hobON0D7scRzzVDzVOodus_xkFyiTm_hS4PIH57eR-g |
| link.rule.ids | 230,309,786,891,25594,76903 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8NADA9jivNNp6LOj0Ok6EOR9WvrQxHbrnS6L0qVPQjj2l6liG3Zqv775s5N97S3y6UcbUqS--WSHMC1yqiudPRUjttaJGuRpsoRVWO5y9qmyZhhdCIe0B-ODP9Ze5zq0xq8r2phRJ_Qb9EcETUqRn2vhL0u_4NYrsitXNxFGU4V915oudISHeP2Bf2X5NpWbzJ2x47kOJYdSKPAmvT5pbSapj-gvd7qICYUWOnF5mUp5bpP8fZge4LL5dU-1MqqCQ1ndfVaE3aGyxNvHC6Vb3EArygE_G_zslgQkWFOScohM0kYwb0f-jIe6Ss4maMFKMhN_pbe4qMfBE2_6KSbUGRmOfnKkJ39Zq-nvKiEHsKV1wsdX8bXnP0JZWYHa5-kHkE9L3J2DEQxqUJ1mqZqgmAEqVhHwJm0467BVNMwT6C1YaHTjdxLaPjhcDAb9EdPLdjl8uZleYp5BvVq_snO0T9X0YWQ6w_gbJTk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=anticorpos+contra+fator+de+crescimento+de+nervo+%28ngf%29+com+estabilidade+in+vivo+intensificada&rft.inventor=WEI+LIU&rft.inventor=JERRY+A.+HALL&rft.inventor=SANDEEP+DUTTA&rft.inventor=DUNCAN+CASSON&rft.inventor=JOHN+POWELL&rft.inventor=ANDREA+BEST&rft.inventor=MARK+MAGINN&rft.date=2016-11-29&rft.externalDBID=A2&rft.externalDocID=BRPI1014445A2 |