COMPOSIÇÃO FARMACÊUTICA E MÉTODO PARA TRATAR CÂNCER

• Main Authors: PAUL A. FITZPATRICK, DANIEL J. WENDT, MUBARACK MUTHALIF, AUGUSTUS O. OKHAMAFE, MICHEL C. VELLARD, SEAN M. BELL, EMIL D. KAKKIS
• Format: Patent
• Language: Portuguese
• Published: 29.10.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokary...