processo para a alquilação de derivados de alquil- ou benzilcianogênio na presença de trialquilaminas ou -fosfinas
Preparation of an alpha , alpha -disubstituted benzyl cyanide (I) involves reacting an alpha -unsubstituted or alpha -monosubstituted analog (II) with an alkylating agent in presence of a base and a tertiary amine or phosphine. Preparation of an alpha , alpha -disubstituted benzyl cyanide of formula...
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Format | Patent |
Language | Portuguese |
Published |
01.12.2009
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Abstract | Preparation of an alpha , alpha -disubstituted benzyl cyanide (I) involves reacting an alpha -unsubstituted or alpha -monosubstituted analog (II) with an alkylating agent in presence of a base and a tertiary amine or phosphine. Preparation of an alpha , alpha -disubstituted benzyl cyanide of formula (I) involves reacting an alpha -unsubstituted or alpha -monosubstituted analog of formula (II) (optionally previously dissolved in an organic solvent) with an alkylating agent of formula R1-X (III) or X-CH2CH2-Z-(CH2)n-X (III') in presence of a base and a tertiary amine or phosphine of formula R7-Q(R8)(R9) (IV). R1 = 1-20C alkyl (optionally substituted by 1-3 Q' or phenyl (itself optionally substituted by 1-3 A or Q')) or 2-20C alkenyl (optionally substituted by 1-3 Q' or phenyl (itself optionally substituted by 1-3 A or Q')); R2 = as R1 or phenyl (optionally substituted by 1-3 Q' A); or R1 + R2 = -CH2CH2-Z-(CH2)n-; R3 = phenyl (optionally substituted by 1-3 A or Q'); R4 = H or as R2; A = 1-6C alkyl; Q' = 3-6C cycloalkyl, OH, ACOO, AO, (1-6C) alkoxy-(1-4C) alkoxy, halo, CF3, CN, NO2, COOH, AOCO, OCH2O, NR5R6CO or NR5R6; R5, R6 = H or A; Z = O, S or NR; R = H, A, benzyl or phenyl; n = 1 or 2; X = halo or 1/2 SO4; R7-R9 = 1-30C alkyl or phenyl; Q = N or P. |
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AbstractList | Preparation of an alpha , alpha -disubstituted benzyl cyanide (I) involves reacting an alpha -unsubstituted or alpha -monosubstituted analog (II) with an alkylating agent in presence of a base and a tertiary amine or phosphine. Preparation of an alpha , alpha -disubstituted benzyl cyanide of formula (I) involves reacting an alpha -unsubstituted or alpha -monosubstituted analog of formula (II) (optionally previously dissolved in an organic solvent) with an alkylating agent of formula R1-X (III) or X-CH2CH2-Z-(CH2)n-X (III') in presence of a base and a tertiary amine or phosphine of formula R7-Q(R8)(R9) (IV). R1 = 1-20C alkyl (optionally substituted by 1-3 Q' or phenyl (itself optionally substituted by 1-3 A or Q')) or 2-20C alkenyl (optionally substituted by 1-3 Q' or phenyl (itself optionally substituted by 1-3 A or Q')); R2 = as R1 or phenyl (optionally substituted by 1-3 Q' A); or R1 + R2 = -CH2CH2-Z-(CH2)n-; R3 = phenyl (optionally substituted by 1-3 A or Q'); R4 = H or as R2; A = 1-6C alkyl; Q' = 3-6C cycloalkyl, OH, ACOO, AO, (1-6C) alkoxy-(1-4C) alkoxy, halo, CF3, CN, NO2, COOH, AOCO, OCH2O, NR5R6CO or NR5R6; R5, R6 = H or A; Z = O, S or NR; R = H, A, benzyl or phenyl; n = 1 or 2; X = halo or 1/2 SO4; R7-R9 = 1-30C alkyl or phenyl; Q = N or P. |
Author | RUDOLF LEHNERT GERHARD KORB HANS-WOLFRAM FLEMMING |
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Snippet | Preparation of an alpha , alpha -disubstituted benzyl cyanide (I) involves reacting an alpha -unsubstituted or alpha -monosubstituted analog (II) with an... |
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SubjectTerms | ACYCLIC OR CARBOCYCLIC COMPOUNDS AMMONIA APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMPOUNDS THEREOF CYANOGEN GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS INORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
Title | processo para a alquilação de derivados de alquil- ou benzilcianogênio na presença de trialquilaminas ou -fosfinas |
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