Formulação reconstituída estável método para a preparação de uma formulação artigo manufaturado e uso da formação

• Main Authors: STEVEN J. SHIRE, XANTHE M. LAM, JEFFREY L. CLELAND, JAMES ANDYA, SYLVIA SAU-YAN WU, CHUNG C. HSU, DAVID E. OVERCASHIER, JANET YU-FENG YANG
• Format: Patent
• Language: Portuguese
• Published: 02.03.1999
• Edition: 6
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared...