Formulação reconstituída estável método para a preparação de uma formulação artigo manufaturado e uso da formação
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared...
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| Main Authors | , , , , , , , |
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| Format | Patent |
| Language | Portuguese |
| Published |
02.03.1999
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| Edition | 6 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein. |
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| AbstractList | A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein. |
| Author | DAVID E. OVERCASHIER JAMES ANDYA JEFFREY L. CLELAND JANET YU-FENG YANG CHUNG C. HSU SYLVIA SAU-YAN WU XANTHE M. LAM STEVEN J. SHIRE |
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| Notes | Application Number: BR19969609743 |
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| Snippet | A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted... |
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| SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| Title | Formulação reconstituída estável método para a preparação de uma formulação artigo manufaturado e uso da formação |
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