Formulação reconstituída estável método para a preparação de uma formulação artigo manufaturado e uso da formação
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | Portuguese |
Published |
02.03.1999
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein. |
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Bibliography: | Application Number: BR19969609743 |