Carbapenems with naphthosultam derivative linked via methylene

The present invention relates to carbapenem antibacterial agents of formula I:or a pharmaceutically acceptable salt thereof, wherein:R2 represents:in formula I, in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH2 group. The naphthosultam is furt...

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Bibliographic Details
Main Authors TIMOTHY A. BLIZZARD, ROBERT R WILKENING, RONALD W RATCLIFFE, JERRY D. MORGAN II
Format Patent
LanguageEnglish
Published 08.03.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to carbapenem antibacterial agents of formula I:or a pharmaceutically acceptable salt thereof, wherein:R2 represents:in formula I, in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH2 group. The naphthosultam is further substituted with various substituent groups including at least one cationic group.
Bibliography:Application Number: AU19980089007