Chemokine recpetor binding heterocyclic compounds

Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.

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Main Authors YUANXI ZHOU, DOMINIQUE SCHOLS, RENATO SKERLJ, TREVOR R. WILSON, SIQIAO NAN, ERNEST J. MCEACHERN, CURTIS HARWIG, GARY BRIDGER, AL KALLER, DAVID BOGUCKI, JASON CRAWFORD, BEM ATSMA
Format Patent
LanguageEnglish
Published 15.07.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.
AbstractList Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.
Author GARY BRIDGER
DAVID BOGUCKI
BEM ATSMA
TREVOR R. WILSON
RENATO SKERLJ
YUANXI ZHOU
SIQIAO NAN
CURTIS HARWIG
JASON CRAWFORD
ERNEST J. MCEACHERN
AL KALLER
DOMINIQUE SCHOLS
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– fullname: TREVOR R. WILSON
– fullname: SIQIAO NAN
– fullname: ERNEST J. MCEACHERN
– fullname: CURTIS HARWIG
– fullname: GARY BRIDGER
– fullname: AL KALLER
– fullname: DAVID BOGUCKI
– fullname: JASON CRAWFORD
– fullname: BEM ATSMA
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Snippet Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Chemokine recpetor binding heterocyclic compounds
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