Recombinant alpha-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
The present invention provides a recombinant human ±-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human, ±-L-iduronidase enzyme as well as methods to treat certain genetic disorders including ±-L-iduronida...
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| Main Authors | , , , , , , , , , |
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| Format | Patent |
| Language | English |
| Published |
03.06.2004
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| Edition | 7 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention provides a recombinant human ±-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human, ±-L-iduronidase enzyme as well as methods to treat certain genetic disorders including ±-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1). |
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| AbstractList | The present invention provides a recombinant human ±-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human, ±-L-iduronidase enzyme as well as methods to treat certain genetic disorders including ±-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1). |
| Author | CHRISTOPHER M. STARR WIA-PAN CHAN LIN CHEN JOHN M. HENDSTRAND BECKY TANAMACHI MINMIN QIN PAUL A. FITZPATRICK EMIL D. KAKKIS DAN J. WENDT GARY N. ZECHERLE |
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| RelatedCompanies | BIOMARIN PHARMACEUTICAL INC HARBOR-UCLA RESEARCH AND EDUCATION INSTITUTE |
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| Snippet | The present invention provides a recombinant human ±-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| Title | Recombinant alpha-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof |
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