Process for the preparation of chiral, nonracemic(4-aryl-2,5-dioxoimidazolidin-1-yl)acetic acids

• Main Authors: BERNDT KULITZSCHER, JURGEN MICHALOWSKY, GERHARD BECK, WOLFGANG HOLLA, BERNHARD KAMMERMEIER
• Format: Patent
• Language: English
• Published: 28.09.2000
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Preparation of chiral, non-racemic compounds of formula (I) comprises carrying out a racemate cleavage of the racemic compound (I) by forming its salt with a chiral, non-racemic amino compound. R1 = H, F, Cl, Br, I, CN, NO2 or OH; R2 = H, F, 1-7C alkyl, phenyl(1-7C)alkyl or 3-8C cycloalkyl. A proces...