MONOCLONAL ANTIBODIES WHICH NEUTRALIZE HIV-1 INFECTION AND THEIR ANTI-IDIOTYPES

Monoclonal antibodies are revealed which bind to the gp120 protein on the envelope of HIV-1, both in the PND region and in the CD4-binding region. These antibodies neutralize HIV-1. They inhibit the infection of T cells, and also inhibit syncytium formation. Further, the antibodies are group-specifi...

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Bibliographic Details
Main Authors TSE WEN CHANG, MICHAEL S. C FUNG, NANCY T. CHANG, BILL N. C SUN, CECILY R. Y SUN
Format Patent
LanguageEnglish
Published 24.07.1991
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Monoclonal antibodies are revealed which bind to the gp120 protein on the envelope of HIV-1, both in the PND region and in the CD4-binding region. These antibodies neutralize HIV-1. They inhibit the infection of T cells, and also inhibit syncytium formation. Further, the antibodies are group-specific and neutralize different strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment and prevention of AIDS and ARC. The antibodies are used in immunotoxins which are specifically toxic to HIV-1 infected T cells. In addition, anti-idiotypic antibodies to these HIV neutralizing antibodies, or derivative products such as chimeric antibodies and human antibody fragments, can be used to immunize against HIV-1.
Bibliography:Application Number: AU7160691