Kit and method for pretargeting

• Main Authors: EBO SYBREN BOS, RICHARD P. MCCABE
• Format: Patent
• Language: English
• Published: 29.05.1997
• Edition: 6
• Subjects: ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; BEER; BIOCHEMISTRY; CHEMISTRY; CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS,e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES,DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; CONVEYING; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HANDLING THIN OR FILAMENTARY MATERIAL; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PACKAGES; PACKAGING ELEMENTS; PACKING; PEPTIDES; PERFORMING OPERATIONS; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPIRITS; STORING; TESTING; TRANSPORTING; VINEGAR; WINE

The invention describes a novel kit or method for the delivery of pharmaceutical or diagnostic compounds to target cells in the body. This kit comprises a monospecific antibody with multiple binding sites, which antibody recognizes a target associated antigen, and a ligand-effector moiety, of which the ligand has been derived from the target associated antigen or analogue thereof. Specifically the invention relates to targeting cytotoxic drugs or radioisotopes to tumor cells. The preferred antibody is a human IgM and the ligand is preferably the epitope cognate to said antibody.