Solid phase synthesis of oligonucleotide n3'$m(7)p5' phosphoramidates

A new class of oligonucleotide N3'->P5' phosphoramidates having 2' fluoro substituents are provided that have superior acid stability. The invention includes oligo-2'-fluoronucleotide N3'->P5' phosphoramidates, methods of synthesis, and duplexes and triplexes form...

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Bibliographic Details
Main Authors RONALD G SCHULTZ, BERNARD L. HIRSCHBEIN, JEFFREY S. NELSON, SARAH N. MCCURDY, SERGEI M GRYAZNOV, KAREN L. FEARON
Format Patent
LanguageEnglish
Published 10.09.1997
Edition6
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:A new class of oligonucleotide N3'->P5' phosphoramidates having 2' fluoro substituents are provided that have superior acid stability. The invention includes oligo-2'-fluoronucleotide N3'->P5' phosphoramidates, methods of synthesis, and duplexes and triplexes formed with DNA and RNA. Compounds of the invention are useful where the formation of stable and specific duplex and/or triplex structures is desired, including antisense and/or anti-gene pharmaceuticals, branched DNA components, DNA and/or RNA capture agents, components of DNA-based diagnostic assays, and the like.
Bibliography:Application Number: AU19960061789