Aryl sulfonic acids and derivatives as fsh antagonists

• Main Authors: JAMES WINFIELD JETTER, JOHN FRANCIS ROGERS, WENLING KAO, JAY EDWARD WROBEL, DANIEL MICHAEL GREEN
• Format: Patent
• Language: English
• Published: 16.10.2000
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention provides compounds of formula (I) having the structure wherein Q is hydrogen or -SO2R ; X is a bond, O, S(O)n, -CH=CH-, -CH2CH2-, -CC-, or -CH2S(O)nCH2-; R is OH, NH2, C1 to C6 alkoxy, C1 to C3 perfluoroalkoxy; Ar is (a) or (b); Ar' is (c) or (d); R and R are each, independently, hydrogen, OR , -S(O)mR , -NHR , -N(R )2, or -CH2SO2CH3; R and R are each, independently, hydrogen, -NO2, -NH2, -SO2R , or -CH2R ; R is hydrogen, C1 to C6 alkyl, C3 to C6 alkenyl, -CH2CH2Z, -CH2COR , -CH2CH=CHCOR , (e), (f) or (g); Y1 and Y are each, independently, N, or CH; Y and Y are each independently, O, S, or NR ; R is -OR , -NHR , -N(R )2, or -NHCH2CH2OR ; Z is -OR8, -OCH2CH2OR , -N(R )2, or (h); R8 is hydrogen or C1 to C3 alkyl; R is C1 to C6 alkyl, C3 to C6 alkenyl, OH, NHR , N(R )2, CH2COR , -CH2CH=CHCOR , or (i); R is C1 to C3 alkyl, C3 to C4 alkenyl, phenyl, -CH2CH2OCH3, or -(j); R is -OR , -NHR , -N(R )2, or -NHCH2CH2OR ; R is hydrogen, or C1 to C3 alkyl; R is hydrogen, or C1 to C3 alkyl; W is a bond, CH2, CH2CH2, O, S(O)q, NCHO, NCOCH3, or NR ; m is 0 - 2; n is 0 - 2; q is 0 - 2, with the proviso that R and R are not both hydrogen; or pharmaceutically acceptable salt thereof, which are useful as contraceptive agents.