Method of purifying a fermentation broth
A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin comp...
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Main Authors | , |
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Format | Patent |
Language | English |
Published |
03.09.2001
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin compound is extracted under acidic conditions into a hydrophobic solvent and purified by crystallization. The organic extraction solvent is concentrated and then extracted with a mild base. The statin compound is then purified by crystallization. |
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Bibliography: | Application Number: AU20010036543 |