The oligosaccharide structure of a ligand for e and p selectin
A specific ligand for E- and P-selectin was isolated from in vivo[ H]-glucosamine labeled HL-60 cells by a combination of weat germ agglutinin agarose and E- or P-selectin rIg-agarose chromatography. The total O-linked oligosaccharides on the purified molecule were released by alkaline hydrolysis in...
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| Main Authors | , |
|---|---|
| Format | Patent |
| Language | English |
| Published |
09.04.1996
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| Edition | 6 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A specific ligand for E- and P-selectin was isolated from in vivo[ H]-glucosamine labeled HL-60 cells by a combination of weat germ agglutinin agarose and E- or P-selectin rIg-agarose chromatography. The total O-linked oligosaccharides on the purified molecule were released by alkaline hydrolysis in the presence of NaBH4 and analyzed by ion-exchange, size-exclusion and paper chromatography in combination with specific exoglycosidase digestions. Various derived ligands and carbohydrates are claimed. |
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| AbstractList | A specific ligand for E- and P-selectin was isolated from in vivo[ H]-glucosamine labeled HL-60 cells by a combination of weat germ agglutinin agarose and E- or P-selectin rIg-agarose chromatography. The total O-linked oligosaccharides on the purified molecule were released by alkaline hydrolysis in the presence of NaBH4 and analyzed by ion-exchange, size-exclusion and paper chromatography in combination with specific exoglycosidase digestions. Various derived ligands and carbohydrates are claimed. |
| Author | AKE P ELHAMMER JIAN-GUO GENG |
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| Snippet | A specific ligand for E- and P-selectin was isolated from in vivo[ H]-glucosamine labeled HL-60 cells by a combination of weat germ agglutinin agarose and E-... |
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| SubjectTerms | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| Title | The oligosaccharide structure of a ligand for e and p selectin |
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